Brightplex® Reveal The Complexity Of Immune Infiltrates

In The Tumor Microenvironment

Identification of complex immune cells phenotype 1 slide, up to 7 biomarkers, cutting-edge image analysis

Brightplex® is an automated workflow that takes advantage of brightfield microscopy, using standardized reagents, proprietary know-how and advanced image analysis to enable the robust analysis of combinations of up to 7 biomarkers on a single slide.  The image processing component of the Brightplex® technology leverages Indica Labs’ HALO™ image analysis platform.

Brightplex® bioinformatics platform allows dedicated analysis of a complete set of data providing unpreceded information on the tumor microenvironment. Basically, specific immune cell populations can be precisely quantified and spatially localized in specific region of interest (tumor, invasive margin, stroma, parenchyma) of the tissue. When associated to clinical information, this powerful set of data are used to help understanding drug’s mechanism of action and drug resistance.

Two panels are currently available: Brightplex® TCE, which identifies exhausted T cells, and Brightplex® MDSC, which identifies two populations of Myeloid-Derived Suppressor-Cells (MDSCs).

Together, these 2 panels provide an invaluable set of tools to analyze the immune contexture of a tumor in translational and clinical research in immuno-oncology to help overcome anti-PD-1/PD-L1 resistance in Lung cancer.

Other indications on existing panels or additional panels could be available on demand.

Poster on Brightplex®

Brightplex® TCE and Brightplex® MDSC have been developped in the context of the PIONeeR project

The development of Brightplex® TCE and Brightplex® MDSC was supported by the French National Research Agency (ANR) in the context of the PIONeeR project, a 5-year research program that aims to better understand, predict and overcome anti-PD-1/PD-L1 resistance in advanced lung cancer patients.



Interested in Brightplex® technology ? Contact us



HalioDx newsletter subscription

Join our newsletter and be the first to get notified on new updates.

× Hide this popup.