Why IMMUNOSCORE® IC?
IMMUNOSCORE® IC is intended for the detection of PD-L1 protein and the concomitant detection of CD8 + cells in Non-Small Cell Lung cancer (NSCLC) tissue.
IMMUNOSCORE® IC, as a member of the IMMUNOSCORE® family assays, is a standardized Immunohistochemistry (IHC)-based assay.
In addition, HalioDx provides image and data analysis services allowing standardized quantification of both PD-L1+ and CD8+ cell populations and the assessment of cells clustering as well as a proximity index. These measures aim to help identifying which NSCLC patients may best respond to anti-PD1 or anti-PD-L1 immunotherapies.
IMMUNOSCORE® IC is available as a CE-IVD assay for PD-L1+ cells detection and as an RUO* solution in the Rest of The World through our comprehensive offer integrating HalioDx service laboratory.
* For Research Use Only. Not for use in diagnostic procedures.
IMMUNOSCORE® IC
Indication: NSCLC
Material: One FFPE slide
Assay: PD-L1+ & CD8+ cells detection by immunohistochemistry
Digital pathology: computation of CD8+ & PD-L1+ cell densities
Score & report: clustering of CD8+ & PD-L1+ cells
and CD8+ & PD-L1+ proximity index
IMMUNOSCORE® IC solution consists in two parts:
- IMMUNOSCORE® IC IHC kit includes ready-to-use anti-PD-L1 and anti-CD8 antibodies and controls for IHC dual-staining. The stained slide is directly readable by the pathologist to determine the percentage of PD-L1 positive tumor cells, evaluate the presence of PDL1+ immune cells and of CD8+ cells.
- Image analysis for complementary descriptive information:
- Standardized computation of CD8+ and PD-L1+ cell densities on the same slide
- PD-L1+ and CD8+ cells clustering
- Proximity index between PD-L1+ and CD8+ cells
Clinical utility
IMMUNOSCORE® IC is intended to help clinicians defining immunotherapy treatment strategy for patients with NSCLC.
Anti-PD-1/PD-L1 are now established treatments for advanced NSCLC patients; however, PD-L1 predictive value is not optimal. Association of PD-L1 + TC % with the assessment of tumor-infiltrating lymphocytes (TILs) via CD8+ T cells quantification and proximity measurement should improve the selection of patients likely to respond to Immune Checkpoint Inhibitors treatment.
See IMMUNOSCORE® IC (previously Halioseek® PD-L1/CD8) Digital Pathology Tool Performance (SITC 2017)
IMMUNOSCORE® IC workflow
How to Order
Depending on your laboratory equipment IMMUNOSCORE® IC is available as a CE-IVD test (Europe only) for PD-L1 assessment directly in your laboratory or in a full service process (performed in HalioDx laboratories) through a standardized and validated workflow. For image analysis services and to access to IMMUNOSCORE® IC documentation, please contact HalioDx.
See our General Terms and Conditions
Posters on IMMUNOSCORE® IC in NSCLC
#poster | avril. 2018
Poster presented at AACR 2018
Multi-centric PD-L1 and CD8 IHC assessment in NSCLC using IMMUNOSCORE® IC previously Halioseek®) CE-IVD assay
#poster | nov.. 2017
Poster presented at SITC 2017
Immunoscore IC (previously Halioseek® PD‐L1/CD8), a dual CD8 and PD‐L1 IVD assay to improve NSCLC patients stratification
#poster | avril. 2017
Poster presented at AACR 2017
A new standardized CD8 and PD-L1 dual assay
Selected publications
Teng MWL et al.
Classifying Cancers Based on T-cell Infiltration and PD-L1
Cancer Res. 2015
Jun 1;75(11):2139-45. doi: 10.1158/0008-5472.CAN-15-0255
More infoTumeh PC et al.
PD-1 blockade induces responses by inhibiting adaptive immune resistance
Nature. 2014
Nov 27;515(7528):568-71. doi: 10.1038/nature13954
More infoTaube JM et al.
Association of PD-1, PD-1 ligands, and other features of the tumor immune microenvironment with response to anti-PD-1 therapy
Clin Cancer Res. 2014
Oct 1;20(19):5064-74. doi: 10.1158/1078-0432.CCR-13-3271
More infoSznol M, Chen L
Antagonist antibodies to PD-1 and B7-H1 (PD-L1) in the treatment of advanced human cancer
Clin Cancer Res. 2013
Mar 1;19(5):1021-34. doi: 10.1158/1078-0432.CCR-12-2063
More infoFridman WH et al.
The immune contexture in human tumours: impact on clinical outcome
Nat Rev Cancer. 2012
Mar 15;12(4):298-306. doi: 10.1038/nrc3245
More info