Frequently Asked Questions All you need to know about our solutions in one single page

FAQ

HalioDx has its GCP laboratory in Marseille, France and two CLIA laboratories : Marseille France and Richmond, Virginia, USA.

HalioDx has developed pharma services for exploratory biomarker testing, Clinical trial assay and CDx developments for all phases of a clinical trial. HalioDx offers testing compliant with GCP (Good Clinical Practice) or GCLP (Good Clinical and Laboratory Practice) requirements for patient testing.

HalioDx can organize shipment of patient samples from recruiting centers if needed.

HalioDx offers single IHC testing on Frozen Samples and FFPE samples.

HalioDx does not do Fluorescence IHC testing but has developed a multiplex IHC technology, Brightplex®, which can combine up-to 7 biomarkers on 1 FFPE slide.

HalioDx can use protocol to transfer it to its lab. However, some development might be required.

HalioDx has developed pharma services for exploratory biomarker testing, Clinical trial assay and CDx developments for all phases of a clinical trial. Samples and testing traceability are compliant.

HalioDx has an expert team for bioinformatics and biostatistics.

HalioDx offers testing for RNA expression and DNA sequencing.

RNA and DNA can be extracted from FFPE tissues or frozen tissues.

HalioDx is doing testing mainly on human tissues. Only Molecular testing can be performed on mice and/or other animals.

IHC testing can be performed only on humanized Mice/ and or other animals.




If your question(s) is/are not included in the list above, please contact us Contact us

Resources on our Biopharma services



#Brightplex® | #Immunogram
Video

#video | août. 2020

2’ to learn more Series: Jacques Fieschi PhD, VP, R&D, presents the R&D department and its technologies, with a focus on Brightplex®
#Immunoscore® CR
Publication

#publication | août. 2020

Bruni D, K Angell H and Galon J

The immune contexture and Immunoscore in cancer prognosis and therapeutic efficacy

Nature Reviews Cancer

#Brightplex®
Poster

#poster | juin. 2020

Unravelling the mystery of cancer-associated fibroblast (CAF) populations in the tumor microenvironment by a fully automated sequential chromogenic multiplex assay

AACR2020 Abstract # 5970

#Immunoscore® CR
Poster

#poster | juin. 2020

Immunoscore workflow enhanced by Artificial Intelligence

AACR2020 Poster # 870

#Brightplex® | #Immunogram | #Immunoscore® CR | #Immunosign® CR
Video

#video | mai. 2020

Webinar: Capturing the Complexity of the Tumor Microenvironment | Jérôme Galon, PhD & Jacques Fieschi, PhD
#Immunogram
Poster

#poster | déc.. 2019

Poster presented at SITC 2019

Immunogram to decipher PD1/L1 ICI resistance: a proof of concept in advanced Non-small cell lung cancer patients of the PIONeeR Project.

#Brightplex® | #Immunogram | #Immunoscore® CR | #Immunosign® CR
Video

#video | nov.. 2019

Webinar: Evaluating Biomarkers During Clinical Trials for Immunotherapies. A Case Study on the Pioneer Project
#Immunoscore® CR | #Immunosign® CR
Poster

#poster | nov.. 2019

Poster presented at ESMO 2019 by Transgene

In the Phase Ib/II trial of TG4001, HalioDx Immunoscore®, Immunosign® and others clinical research service have been performed to assess Immune contexture of patients.

#Immunoscore® CR
Poster

#poster | nov.. 2019

Poster presented at SITC 2019

Tumor Infiltrating Lymphocytes (TILs) in triple-negative breast cancer: High Immunoscore is associated with pathological CR in patients receiving neoadjuvant chemotherapy.

#Immunoscore® CR
Poster

#poster | nov.. 2019

Poster presented at ESMO 2019

High Immunoscore® is associated with good response to neo-adjuvant chemotherapy and prolonged survival in advanced Head and Neck cancer patients.

#Immunogram
Poster

#poster | nov.. 2019

Poster presented at SITC 2019

Unveilling tumor-associated macrophages (TAMs) heterogeneity and plasticity by a fully automated sequential chromogenic multiplex assay.

#Immunogram
Poster

#poster | nov.. 2019

Poster presented at SITC 2019

Cancer Immunogram: combining multi-parameter approach and machine learning to capture the complexity of tumor immune contexture.

#Immunogram
Video

#video | sept.. 2019

Webinar Biomarker Evaluation for CAR T-Cell Therapy: Impact on Drug Development
#Immunoscore® CR
Publication

#publication | août. 2019

Angell HK, Bruni D, Barrett JC et al.

The Immunoscore: Colon Cancer and Beyond.

Clin Cancer Res.

#Immunoscore® CR
Publication

#publication | juil.. 2019

Mascaux C, Angelova M, Vasaturo A et al.

Immune evasion before tumour invasion in early lung squamous carcinogenesis.

Nature

#Immunoscore® CR | #Immunosign® CR
Video

#video | juil.. 2019

HalioDX is part of the COLOSSUS project by performing Immunoscore and help stratification of difficult to treat mCRC patients with a final objective to Improve their management and treatment
#Brightplex®
Video

#video | juin. 2019

Webinar on Brightplex®: Combining the power of multiplexing & the ease of chromogenic IHC to assess complex immune phenotype
#Immunoscore® CR
Video

#video | juin. 2019

Jérôme Galon, winner for the European Inventor Award 2019 for Immunoscore®
#Immunoscore® CR
Publication

#publication | mai. 2019

Pages F, Andre T, Taieb J et al.

Validation of the Immunoscore prognostic value in stage III colon cancer patients treated with oxaliplatin in the prospective IDEA France cohort study (PRODIGE-GERCOR)

Journal of Clinical Oncology

#Immunoscore® CR
Publication

#publication | mai. 2019

Galon J & Bruni D

Tumor Immunology and Tumor Evolution: Intertwined Histories

Immunity

#Immunogram
Video

#video | avril. 2019

Immunogram Clinical Seminar (Atlanta, April 2019) | Jacques Fieschi, PhD
#Immunogram
Video

#video | avril. 2019

Immunogram Clinical Seminar (Atlanta, April 2019) | Jérôme Galon, PhD
#Immunogram
Poster

#poster | avril. 2019

Poster presented at AACR 2019

Combining multimodal biomarkers as an immunogram to guide immunotherapy use: A Proof of Concept

#Immunosign® CR
Poster

#poster | avril. 2019

Poster presented at AACR 2019 by Lytix biopharma

A phase I study of the oncolytic peptide LTX-315 generates de novo T-cell responses and clinical benefits in patients with advanced sarcoma

#Immunosign® CR
Poster

#poster | avril. 2019

Poster presented at AACR 2019 by Lytix biopharma

A phase I study of the oncolytic peptide LTX-315 generates de novo T-cell responses and clinical benefit in patients with advanced melanoma

#Brightplex® | #Immunoscore® CR
Poster

#poster | avril. 2019

Poster presented at AACR 2019

Validation of Brightplex®, a multiplex IHC solution for immune cell phenotyping of the tumor microenvironment

#Immunoscore® CR
Publication

#publication | mars. 2019

Zeitoun G, Sissy CE, Kirilovsky A et al.

The Immunoscore in the Clinical Practice of Patients with Colon and Rectal Cancers.

Chirurgia (Bucur).

#Brightplex® | #Immunogram | #Immunoscore® CR | #Immunosign® CR
Brochure

#brochure | mars. 2019

Brochure Clinical Research

HalioDx Biopharma Services

#Immunoscore® CR
Publication

#publication | mars. 2019

Galon J & Bruni D

Approaches to treat immune hot, altered and cold tumours with combination immunotherapies.

Nat Rev Drug Discov.

#Brightplex® | #Immunoscore® CR
Poster

#poster | nov.. 2018

Poster presented at SITC 2018

Myeloid-derived suppressor cells (MDSC) assessment using an automated sequential chromogenic multiplex assay (Brightplex®)

#Immunoscore® CR
Publication

#publication | oct.. 2018

Angelova M, Mlecnik B, Vasaturo A et al.

Evolution of Metastases in Space and Time under Immune Selection.

Cell

#Brightplex® | #Immunoscore® CR
Poster

#poster | oct.. 2018

Poster presented at the CRI-CIMT-EATI-AACR 2018

T cell exhaustion assessment using an automated sequential chromogenic multiplex assay (Brightplex®)

#Immunosign® CR
Poster

#poster | juin. 2018

Poster presented at ASCO 2018 by Lytix biopharma

A Phase I/II study of the oncolytic peptide LTX-315 combined with checkpoint inhibition generates de novo T-cell responses and clinical benefit in patients with advanced solid tumors

#Immunoscore® CR
Publication

#publication | déc.. 2017

Fridman WH, Zitvogel L, Sautès-Fridman C, Kroemer G

The immune contexture in cancer prognosis and treatment.

Nat Rev Clin Oncol.

#Immunosign® CR
Poster

#poster | nov.. 2017

Poster presented at SITC 2017 by Lytix biopharma

LTX-315, a first in class oncolytic peptide, reshapes the tumor microenvironment in the patients with advanced metastatic tumors: Results from an ongoing study

#Brightplex® | #Immunoscore® CR
Poster

#poster | sept.. 2017

Poster presented at NSH 2017

A multiplex immunohistochemistry assay for immune cells profiling on whole FFPE tumor tissue sections

#Immunosign® CR
Poster

#poster | juin. 2017

Poster presented at ASCO 2017 by Kite Pharma
#Immunosign® CR
Poster

#poster | juin. 2017

Poster presented at ASCO 2017 by Lytix biopharma

LTX-315, a first in class oncolytic peptide reshapes the tumor microenvironment inducing a local and systemic effect in metastatic tumors: Results from an ongoing study

#Immunoscore® CR
Publication

#publication | févr.. 2016

Mlecnik B, Bindea G, Kirilovsky A et al.

The tumor microenvironment and Immunoscore are critical determinants of dissemination to distant metastasis.

Sci Transl Med.

#Immunoscore® CR
Publication

#publication | juin. 2015

Berghoff AS, Fuchs E, Ricken G et al.

Density of tumor-infiltrating lymphocytes correlates with extent of brain edema and overall survival time in patients with brain metastases.

Oncoimmunology

#Immunoscore® CR
Publication

#publication | oct.. 2013

Bindea G, Mlecnik B, Tosolini M et al.

Spatiotemporal dynamics of intratumoral immune cells reveal the immune landscape in human cancer.

Immunity

#Immunoscore® CR
Publication

#publication | juil.. 2013

Galon J, Angell HK, Bedognetti D, Marincola FM

The continuum of cancer immunosurveillance: prognostic, predictive, and mechanistic signatures.

Immunity

#Immunoscore® CR
Publication

#publication | mars. 2012

Fridman WH, Pagès F, Sautès-Fridman C, Galon J.

The immune contexture in human tumours: impact on clinical outcome.

Nat Rev Cancer.

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