What can HalioDx do for you?

What can HalioDx do for you?

HalioDx has developed customized services to guide biopharmas in their clinical programs and help them to predict patient response to immunotherapy.

Our Immunoscore®CR assays using Brightplex® innovative technology sign our unique approach to TME exploration and are the pillars of our multimodal analysis platform, Immunogram.

To get a full insight into the tumor immune contexture, you can also access to our Atlas customized multimarker database designed for each cancer indication.

We provide a high level of support to our partners ensuring a successful biomarker strategy approach during your clinical trials, from early phase to late stage.

Our expert dedicated team along with our capabilities in development, clinical research, manufacturing, regulatory and commercialization will accompany each of our pharma partners in their project with a tailored and personalized approach depending on their needs :

  • Understand the Mechanism of action,
  • Identify responders to immune checkpoint inhibitors,
  • Monitor changes in immune response in your clinical trials,
  • Conduct the development of Companion Diagnostic Tests (CDX) eligible for a co-registration with the FDA.

Strong and multiple pieces of evidence

Resources on our Biopharma services



#Brightplex®
Poster

#poster | Jun. 2020

Unravelling the mystery of cancer-associated fibroblast (CAF) populations in the tumor microenvironment by a fully automated sequential chromogenic multiplex assay

AACR2020 Abstract # 5970

#Immunoscore® CR
Poster

#poster | Jun. 2020

Immunoscore workflow enhanced by Artificial Intelligence

AACR2020 Poster # 870

#Brightplex® | #Immunogram | #Immunoscore® CR | #Immunosign® CR
Video

#video | May. 2020

Webinar: Capturing the Complexity of the Tumor Microenvironment | Jérôme Galon, PhD & Jacques Fieschi, PhD
#Immunogram
Poster

#poster | Dec. 2019

Poster presented at SITC 2019

Immunogram to decipher PD1/L1 ICI resistance: a proof of concept in advanced Non-small cell lung cancer patients of the PIONeeR Project.

#Brightplex® | #Immunogram | #Immunoscore® CR | #Immunosign® CR
Video

#video | Nov. 2019

Webinar: Evaluating Biomarkers During Clinical Trials for Immunotherapies. A Case Study on the Pioneer Project
#Immunoscore® CR | #Immunosign® CR
Poster

#poster | Nov. 2019

Poster presented at ESMO 2019 by Transgene

In the Phase Ib/II trial of TG4001, HalioDx Immunoscore®, Immunosign® and others clinical research service have been performed to assess Immune contexture of patients.

#Immunoscore® CR
Poster

#poster | Nov. 2019

Poster presented at SITC 2019

Tumor Infiltrating Lymphocytes (TILs) in triple-negative breast cancer: High Immunoscore is associated with pathological CR in patients receiving neoadjuvant chemotherapy.

#Immunoscore® CR
Poster

#poster | Nov. 2019

Poster presented at ESMO 2019

High Immunoscore® is associated with good response to neo-adjuvant chemotherapy and prolonged survival in advanced Head and Neck cancer patients.

#Immunogram
Poster

#poster | Nov. 2019

Poster presented at SITC 2019

Unveilling tumor-associated macrophages (TAMs) heterogeneity and plasticity by a fully automated sequential chromogenic multiplex assay.

#Immunogram
Poster

#poster | Nov. 2019

Poster presented at SITC 2019

Cancer Immunogram: combining multi-parameter approach and machine learning to capture the complexity of tumor immune contexture.

#Immunogram
Video

#video | Sep. 2019

Webinar Biomarker Evaluation for CAR T-Cell Therapy: Impact on Drug Development
#Immunoscore® CR
Publication

#publication | Aug. 2019

Angell HK, Bruni D, Barrett JC et al.

The Immunoscore: Colon Cancer and Beyond.

Clin Cancer Res.

#Immunoscore® CR
Publication

#publication | Jul. 2019

Mascaux C, Angelova M, Vasaturo A et al.

Immune evasion before tumour invasion in early lung squamous carcinogenesis.

Nature

#Immunoscore® CR | #Immunosign® CR
Video

#video | Jul. 2019

HalioDX is part of the COLOSSUS project by performing Immunoscore and help stratification of difficult to treat mCRC patients with a final objective to Improve their management and treatment
#Brightplex®
Video

#video | Jun. 2019

Webinar on Brightplex®: Combining the power of multiplexing & the ease of chromogenic IHC to assess complex immune phenotype
#Immunoscore® CR
Video

#video | Jun. 2019

Jérôme Galon, winner for the European Inventor Award 2019 for Immunoscore®
#Immunoscore® CR
Publication

#publication | May. 2019

Galon J & Bruni D

Tumor Immunology and Tumor Evolution: Intertwined Histories

Immunity

#Immunoscore® CR
Publication

#publication | May. 2019

Pages F, Andre T, Taieb J et al.

Validation of the Immunoscore prognostic value in stage III colon cancer patients treated with oxaliplatin in the prospective IDEA France cohort study (PRODIGE-GERCOR)

Journal of Clinical Oncology

#Immunogram
Video

#video | Apr. 2019

Immunogram Clinical Seminar (Atlanta, April 2019) | Jérôme Galon, PhD
#Immunogram
Video

#video | Apr. 2019

Immunogram Clinical Seminar (Atlanta, April 2019) | Jacques Fieschi, PhD
#Immunogram
Poster

#poster | Apr. 2019

Poster presented at AACR 2019

Combining multimodal biomarkers as an immunogram to guide immunotherapy use: A Proof of Concept

#Immunosign® CR
Poster

#poster | Apr. 2019

Poster presented at AACR 2019 by Lytix biopharma

A phase I study of the oncolytic peptide LTX-315 generates de novo T-cell responses and clinical benefit in patients with advanced melanoma

#Immunosign® CR
Poster

#poster | Apr. 2019

Poster presented at AACR 2019 by Lytix biopharma

A phase I study of the oncolytic peptide LTX-315 generates de novo T-cell responses and clinical benefits in patients with advanced sarcoma

#Brightplex® | #Immunoscore® CR
Poster

#poster | Apr. 2019

Poster presented at AACR 2019

Validation of Brightplex®, a multiplex IHC solution for immune cell phenotyping of the tumor microenvironment

#Immunoscore® CR
Publication

#publication | Mar. 2019

Zeitoun G, Sissy CE, Kirilovsky A et al.

The Immunoscore in the Clinical Practice of Patients with Colon and Rectal Cancers.

Chirurgia (Bucur).

#Brightplex® | #Immunogram | #Immunoscore® CR | #Immunosign® CR
Brochure

#brochure | Mar. 2019

Brochure Clinical Research

HalioDx Biopharma Services

#Immunoscore® CR
Publication

#publication | Mar. 2019

Galon J & Bruni D

Approaches to treat immune hot, altered and cold tumours with combination immunotherapies.

Nat Rev Drug Discov.

#Brightplex® | #Immunoscore® CR
Poster

#poster | Nov. 2018

Poster presented at SITC 2018

Myeloid-derived suppressor cells (MDSC) assessment using an automated sequential chromogenic multiplex assay (Brightplex®)

#Immunoscore® CR
Publication

#publication | Oct. 2018

Angelova M, Mlecnik B, Vasaturo A et al.

Evolution of Metastases in Space and Time under Immune Selection.

Cell

#Brightplex® | #Immunoscore® CR
Poster

#poster | Oct. 2018

Poster presented at the CRI-CIMT-EATI-AACR 2018

T cell exhaustion assessment using an automated sequential chromogenic multiplex assay (Brightplex®)

#Immunosign® CR
Poster

#poster | Jun. 2018

Poster presented at ASCO 2018 by Lytix biopharma

A Phase I/II study of the oncolytic peptide LTX-315 combined with checkpoint inhibition generates de novo T-cell responses and clinical benefit in patients with advanced solid tumors

#Immunoscore® CR
Publication

#publication | Dec. 2017

Fridman WH, Zitvogel L, Sautès-Fridman C, Kroemer G

The immune contexture in cancer prognosis and treatment.

Nat Rev Clin Oncol.

#Immunosign® CR
Poster

#poster | Nov. 2017

Poster presented at SITC 2017 by Lytix biopharma

LTX-315, a first in class oncolytic peptide, reshapes the tumor microenvironment in the patients with advanced metastatic tumors: Results from an ongoing study

#Brightplex® | #Immunoscore® CR
Poster

#poster | Sep. 2017

Poster presented at NSH 2017

A multiplex immunohistochemistry assay for immune cells profiling on whole FFPE tumor tissue sections

#Immunosign® CR
Poster

#poster | Jun. 2017

Poster presented at ASCO 2017 by Kite Pharma
#Immunosign® CR
Poster

#poster | Jun. 2017

Poster presented at ASCO 2017 by Lytix biopharma

LTX-315, a first in class oncolytic peptide reshapes the tumor microenvironment inducing a local and systemic effect in metastatic tumors: Results from an ongoing study

#Immunoscore® CR
Publication

#publication | Feb. 2016

Mlecnik B, Bindea G, Kirilovsky A et al.

The tumor microenvironment and Immunoscore are critical determinants of dissemination to distant metastasis.

Sci Transl Med.

#Immunoscore® CR
Publication

#publication | Jun. 2015

Berghoff AS, Fuchs E, Ricken G et al.

Density of tumor-infiltrating lymphocytes correlates with extent of brain edema and overall survival time in patients with brain metastases.

Oncoimmunology

#Immunoscore® CR
Publication

#publication | Oct. 2013

Bindea G, Mlecnik B, Tosolini M et al.

Spatiotemporal dynamics of intratumoral immune cells reveal the immune landscape in human cancer.

Immunity

#Immunoscore® CR
Publication

#publication | Jul. 2013

Galon J, Angell HK, Bedognetti D, Marincola FM

The continuum of cancer immunosurveillance: prognostic, predictive, and mechanistic signatures.

Immunity

#Immunoscore® CR
Publication

#publication | Mar. 2012

Fridman WH, Pagès F, Sautès-Fridman C, Galon J.

The immune contexture in human tumours: impact on clinical outcome.

Nat Rev Cancer.

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