Publications: HalioDx

F Pages, J Taieb, P Laurent-Puig, and J Galon

The consensus Immunoscore in phase 3 clinical trials; potential impact on patient management decisions

OncoImmunology

https://doi.org/10.1080/2162402X.2020.1812221

A Lanzi,F Pages, C Lagorce-Pages, and J Galon

The consensus immunoscore: toward a new classification of colorectal cancer

OncoImmunology

https://doi.org/10.1080/2162402X.2020.1789032

https://www.tandfonline.com/doi/full/10.1080/2162402X.2020.1789032

A Lanzi,F.A Sinicrope, A.B Benson, and J Galon

The consensus Immunoscore in phase 3 clinical trial (N0147) and impact on patient management decisions

OncoImmunology

https://doi.org/10.1080/2162402X.2020.1796003

El Sissy C, Kirilovsky A, Van den Eynde M et al.

A Diagnostic Biopsy-Adapted Immunoscore Predicts Response to Neoadjuvant Treatment and Selects Patients with Rectal Cancer Eligible for a Watch-and-Wait Strategy

Clin Cancer Res

10.1158/1078-0432.CCR-20-0337

https://clincancerres.aacrjournals.org/content/early/2020/08/21/1078-0432.CCR-20-0337

Mlecnik B Bifulco C, Bindea G, et al.

Multicenter International Society for Immunotherapy of Cancer Study of the Consensus Immunoscore for the Prediction of Survival and Response to Chemotherapy in Stage III Colon Cancer

J Clin Oncol.

DOI: 10.1200/JCO.19.03205

https://ascopubs.org/doi/abs/10.1200/JCO.19.03205

Bruni D, K Angell H and Galon J

The immune contexture and Immunoscore in cancer prognosis and therapeutic efficacy

Nature Reviews Cancer

doi: 10.1038/s41568-020-0285-7

https://www.nature.com/articles/s41568-020-0285-7

O’Connor JM, Esteso F & Chacón M

Official French SARS-CoV-2 guidelines for cancer patients, a triage solution with precision medicine

Future Medicine

Colorectal Cancer | Ahead of Print

https://www.futuremedicine.com/doi/10.2217/crc-2020-0018

Blair H

Immunoscore®: A Diagnostic Assay for Clinical Management of Colon Cancer

Molecular Diagnosis & Therapy volume

24, pages365–370(2020)

https://link.springer.com/article/10.1007/s40291-020-00459-6

Marliot F, Chen X, Kirilovsky A et al.

Analytical validation of the Immunoscore and its associated prognostic value in patients with colon cancer

BMJ

http://dx.doi.org/10.1136/jitc-2019-000272

https://jitc.bmj.com/content/8/1/e000272

Sinicrope F, Shi Q, Hermitte F et al.

Contribution of Immunoscore and Molecular Features to Survival Prediction in Stage III Colon Cancer

JNCI Cancer Spectrum

Volume 4, Issue 3, June 2020, pkaa023

https://academic.oup.com/jncics/article/4/3/pkaa023/5812786

Pages F, Andre T, Taieb J et al.

Prognostic and Predictive Value of the Immunoscore in Stage III Colon Cancer Patients Treated With Oxaliplatin in the Prospective IDEA France PRODIGE-GERCOR Cohort Study

Annals of Oncology

PMID: 32294529

https://pubmed.ncbi.nlm.nih.gov/32294529/

Pages F, Andre T, Taieb J et al.

Validation of the Immunoscore prognostic value in stage III colon cancer patients treated with oxaliplatin in the prospective IDEA France cohort study (PRODIGE-GERCOR)

Journal of Clinical Oncology

Volume 37, Issue 15_suppl

https://ascopubs.org/doi/abs/10.1200/JCO.2019.37.15_suppl.3513

Galon J & Bruni D

Tumor Immunology and Tumor Evolution: Intertwined Histories

Immunity

https://doi.org/10.1016/j.immuni.2019.12.018

https://www.cell.com/immunity/fulltext/S1074-7613(19)30537-0

Galon J & Bruni D

Approaches to treat immune hot, altered and cold tumours with combination immunotherapies.

Nat Rev Drug Discov.

18(3):197-218

https://www.ncbi.nlm.nih.gov/pubmed/30610226

Mlecnik B, Bindea G, Angell HK et al.

Integrative Analyses of Colorectal Cancer Show Immunoscore Is a Stronger Predictor of Patient Survival Than Microsatellite Instability.

Immunity

44(3):698-711

https://www.ncbi.nlm.nih.gov/pubmed/26982367

Galon J, Costes A, Sanchez-Cabo F et al.

Type, density, and location of immune cells within human colorectal tumors predict clinical outcome.

Science

313(5795):1960-4

https://www.ncbi.nlm.nih.gov/pubmed/17008531

Pagès F, Kirilovsky A, Mlecnik B et al.

In situ cytotoxic and memory T cells predict outcome in patients with early-stage colorectal cancer.

Journal of Clinical Oncology

27(35):5944-51

https://www.ncbi.nlm.nih.gov/pubmed/19858404

Mlecnik B, Tosolini M, Kirilovsky A et al.

Histopathologic-based prognostic factors of colorectal cancers are associated with the state of the local immune reaction.

Journal of Clinical Oncology

29(6):610-8

https://www.ncbi.nlm.nih.gov/pubmed/21245428

Kirilovsky A, Marliot F, El Sissy C et al.

Rational bases for the use of the Immunoscore in routine clinical settings as a prognostic and predictive biomarker in cancer patients.

Int Immunol.

28(8):373-82

https://www.ncbi.nlm.nih.gov/pubmed/27121213

Pagès F, Mlecnik B, Marliot F et al.

International validation of the consensus Immunoscore for the classification of colon cancer: a prognostic and accuracy study.

Lancet

391 (10135)

https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(18)30789-X/fulltext

Sinicrope F, Shi Q, Hermitte F et al.

Association of immune markers and Immunoscore with survival of stage III colon carcinoma (CC) patients (pts) treated with adjuvant FOLFOX: NCCTG N0147 (Alliance).

J Clin Oncol.

35:15s (suppl; abstr 3579)

https://ascopubs.org/doi/abs/10.1200/JCO.2017.35.15_suppl.3579

Sinicrope F, Shi Q, Hermitte F et al.

Immunoscore to provide prognostic information in low- (T1-3N1) and high-risk (T4 or N2) subsets of stage III colon carcinoma patients treated with adjuvant FOLFOX in a phase III trial (NCCTG N0147; Alliance).

J Clin Oncol.

36:4s (suppl; abstr 614)

https://ascopubs.org/doi/abs/10.1200/JCO.2018.36.4_suppl.614

Angelova M, Mlecnik B, Vasaturo A et al.

Evolution of Metastases in Space and Time under Immune Selection.

Cell

10.1016/j.cell.2018.09.018

https://www.cell.com/cell/fulltext/S0092-8674(18)31230-3

Fridman WH, Pagès F, Sautès-Fridman C, Galon J.

The immune contexture in human tumours: impact on clinical outcome.

Nat Rev Cancer.

12(4):298-306

https://www.ncbi.nlm.nih.gov/pubmed/22419253

Galon J, Angell HK, Bedognetti D, Marincola FM

The continuum of cancer immunosurveillance: prognostic, predictive, and mechanistic signatures.

Immunity

39(1):11-26

https://www.ncbi.nlm.nih.gov/pubmed/23890060

Bindea G, Mlecnik B, Tosolini M et al.

Spatiotemporal dynamics of intratumoral immune cells reveal the immune landscape in human cancer.

Immunity

39(4):782-95

https://www.ncbi.nlm.nih.gov/pubmed/24138885

Berghoff AS, Fuchs E, Ricken G et al.

Density of tumor-infiltrating lymphocytes correlates with extent of brain edema and overall survival time in patients with brain metastases.

Oncoimmunology

5(1):e1057388

https://www.ncbi.nlm.nih.gov/pubmed/26942067

Mlecnik B, Bindea G, Kirilovsky A et al.

The tumor microenvironment and Immunoscore are critical determinants of dissemination to distant metastasis.

Sci Transl Med.

8(327):327ra26

https://www.ncbi.nlm.nih.gov/pubmed/26912905

Galon J, Mlecnik B, Marliot F et al.

Validation of the Immunoscore (IM) as a prognostic marker in stage I/II/III colon cancer: Results of a worldwide consortium-based analysis of 1,336 patients.

J Clin Oncol.

JCO.2016.34.15_suppl.3500

https://ascopubs.org/doi/abs/10.1200/JCO.2016.34.15_suppl.3500

Hermitte F

Biomarkers immune monitoring technology primer: Immunoscore® Colon.

Journal for ImmunoTherapy of Cancer

doi:10.1186/s40425-016-0161-x

https://jitc.biomedcentral.com/articles/10.1186/s40425-016-0161-x

Fridman WH, Zitvogel L, Sautès-Fridman C, Kroemer G

The immune contexture in cancer prognosis and treatment.

Nat Rev Clin Oncol.

14(12):717-734

https://www.ncbi.nlm.nih.gov/pubmed/28741618

Mlecnik B, Van den Eynde M, Bindea G et al.

Comprehensive Intrametastatic Immune Quantification and Major Impact of Immunoscore on Survival.

J Natl Cancer Inst.

1;110(1)

https://www.ncbi.nlm.nih.gov/pubmed/28922789

Angell HK, Bruni D, Barrett JC et al.

The Immunoscore: Colon Cancer and Beyond.

Clin Cancer Res.

doi: 10.1158/1078-0432

https://www.ncbi.nlm.nih.gov/pubmed/31413009

Zeitoun G, Sissy CE, Kirilovsky A et al.

The Immunoscore in the Clinical Practice of Patients with Colon and Rectal Cancers.

Chirurgia (Bucur).

114(2):152-161

https://www.ncbi.nlm.nih.gov/pubmed/31060646

Mascaux C, Angelova M, Vasaturo A et al.

Immune evasion before tumour invasion in early lung squamous carcinogenesis.

Nature

571(7766):570-575

https://www.ncbi.nlm.nih.gov/pubmed/31243362