Brightplex Reveal The Complexity Of Immune Infiltrates

In The Tumor Microenvironment

A novel high capacity IHC multiplex technology that analyzes up to 7 biomarkers on a single FFPE slide

Brightplex is an automated workflow that takes advantage of brightfield microscopy, using standardized reagents, proprietary know-how and advanced image analysis to enable the robust analysis of combinations of up to 7 biomarkers on a single slide.  The image processing component of the Brightplex technology leverages Indica Labs’ HALO™ image analysis platform.

Brightplex bioinformatics platform allows dedicated analysis of a complete set of data providing unpreceded information on the tumor microenvironment. Basically, specific immune cell populations can be precisely quantified and spatially localized in specific region of interest (tumor, invasive margin, stroma, parenchyma) of the tissue. When associated to clinical information, this powerful set of data are used to help understanding drug’s mechanism of action and drug resistance.

Two panels are currently available: Brightplex TCE, which identifies exhausted T cells, and Brightplex MDSC, which identifies two populations of Myeloid-Derived Suppressor-Cells (MDSCs).

Together, these 2 panels provide an invaluable set of tools to analyze the immune contexture of a tumor in translational and clinical research in immuno-oncology to help overcome anti-PD-1/PD-L1 resistance in Lung cancer.

Other indications on existing panels or additional panels could be available on demand.


Poster on Brightplex TCE presented at the CRI-CIMT-EATI-AACR Conference 2018

Brightplex TCE and Brightplex MDSC have been developped in the context of the PIONeeR project

The development of Brightplex TCE and Brightplex MDSC was supported by the French National Research Agency (ANR) in the context of the PIONeeR project, a 5-year research program that aims to better understand, predict and overcome anti-PD-1/PD-L1 resistance in advanced lung cancer patients.

 

 

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