Tumors consist of a mixture of neoplastic epithelial cells, endothelial cells, fibroblasts, myofibroblasts, and immune cells, which collectively form the tumor microenvironment (Fridman et al., Nature Reviews Cancer 2012). The complex interplay between these cells including the type, density, location and immune functions, is implicated in disease progression, metastasis, and drug response/resistance and form the paradigm of the immune contexture (Galon J et al. Science 2006).
Deciphering immune genes expression of the tumor micro environment provides insight on the immune functions orientation and has thus the potential to predict cancer immunotherapy interventions (E Wang et al., JCO 2013).
A flexible service solution allowing to investigate the prognostic and predictive performances of quantifying immune cells in a variety of cancer types
Delivering new information by combining PD-L1 expression with densities of CD8+ cells and an analysis of proximity between PDL1+ and CD8+ cells