Tumors consist of a mixture of neoplastic epithelial cells, endothelial cells, fibroblasts, myofibroblasts, and immune cells, which collectively form the tumor microenvironment. The association of immune cell infiltrates with prognosis, in various types of cancer, has been demonstrated in a large number of publications (see Nature Reviews Cancer 2012, Fridman et al.). The complex interplay between these cells including the type, density, location and immune functions, is implicated in disease progression, metastasis, and drug response/resistance and form the paradigm of the immune contexture (Galon J et al. Science 2006).
Delivering new information by combining PD-L1 expression with densities of CD8+ cells and an analysis of proximity between PDL1+ and CD8+ cells
A flexible service solution allowing to investigate the prognostic and predictive performances by measuring the level of expression of selected immune genes on RNA extracted